This number is a prime.

+ The German beer Köstritzer dates back to 1543. [Luhn]

+ The year of publication of three landmarks in science: Andreas Vesalius published his De humani corporis fabrica libri septem (Basel: Johannes Oporinus), Nicolaus Copernic his De revolutionibus orbium celestium (Nuremberg: Johannes Petreius), and Robert Recorde his Arithmetic or the ground of Arts (London: Thomas Harper for John Harison). [Olry]

+ 1543 and the 1543rd emirp (928607) contain the ten digits once each. [Gaydos]

(There are 4 curios for this number that have not yet been approved by an editor.)

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